Proteins found in cancer extracellular vesicles could guide drug development

Cancer cells release tiny biological packages called extracellular vesicles (EVs) that help tumors grow and spread. A team ...
GEN - Genetic Engineering and Biotechnology News

DNA-Containing Extracellular Vesicles Boost Antitumor Responses in Mice

Findings identify strategy for boosting anticancer immunity and potentially a new tool for delivering genetic payloads to ...

T cells secrete DNA to boost the immune system's cancer-fighting ability

Activated immune cells secrete tiny capsules bearing DNA that can enter other immune and tumor cells to stimulate the body's defense systems, according to a study led by investigators at Weill Cornell ...
Phys.org

Phospholipid asymmetry helps explain extracellular vesicle surface charge and therapeutic quality

Extracellular vesicles (EVs) are nanoscale lipid bilayer particles secreted by cells that mediate intercellular communication by transporting biomolecules such as proteins and RNA. Among them, ...
Frontiers

Extracellular Vesicles in Platinum Drug Resistance: Unifying Molecular Mechanisms, Multi-Cancer Biomarkers, and Therapeutic Strategies

Platinum-based chemotherapy is foundational in the management of a wide range of solid malignancies, yet the emergence of drug resistance sharply limits ...
ascopubs.org

Tumor neutrophil extracellular traps and pretreatment neutrophils in association with progression-free survival in patients with metastatic non-small cell lung cancer receiving ...

Clinical outcomes of immune checkpoint inhibitors in HER2-amplified non-small cell lung cancers. This is an ASCO Meeting Abstract from the 2022 ASCO Annual Meeting I. This abstract does not include a ...